Eileen is a recognized and respected civic and community leader, serving as mayor of Independence, Missouri from 2014 -2022. During her tenure as mayor and beyond, she has amassed an extensive list of notable accomplishments. One of her significant achievements was the development and implementation of the "Independence for All" Strategic Plan, which was unanimously adopted by the City Council in 2017. This plan, the city's first published strategic plan, included quarterly online performance measures and was developed through extensive engagement with citizens, businesses, school districts, and civic leaders. 

Weir also played a key role in the creation and adoption of the "Imagine Independence 2040 - A Community Vision" Comprehensive Development Plan in 2018. This plan, recognized by the American Planning Association, outlined a vision and blueprint for public and private investment in the downtown district over a 20-year period. Furthermore, she led the Downtown Redevelopment Coordinating Committee, which aimed to redefine the downtown district and facilitate public and private investment. 

Under Weir's leadership, the Independence Uptown Market was opened in 2018. This $3.3 million project repurposed a city surface parking lot and has received multiple awards and recognitions, including the Design Build Association of America's Project of the Year.

Additionally, Weir established the Independence Economic Development and Incentives Commission to improve transparency in publicly subsidized development projects. 

Weir's commitment to diversity and inclusion is evident through her appointment of the Mayor's Diversity and Inclusion Task Force, which provided advice and guidance on police policies and racial inclusion and equity. She also restored the Local Public Health Authority designation to the Independence Health Department, allowing for the issuance of public health orders and funding during the COVID-19 pandemic. 

Weir served as a member of the Truman Library Institute Board of Trustees, where she played a significant role in fundraising $53million for the renovation of the Truman Library. She has also held positions on various boards and committees, such as the ArtsKC Board of Directors, MidAmerica Regional Council Board of Directors, Greater Kansas City Chamber of Commerce Board of Directors, and the Mid-America LGBT Chamber of Commerce.

Weir’s passion for economic development, policy advancements, community engagement, and civic leadership, continues to make significant impacts on the city she loves and its residents.